IImmune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells
نویسندگان
چکیده
In assessing your manuscript I note that you describe a model for cancer cell migration under bacterial infection conditions. You show that hindgut cells overexpressing an activated form of Ras acquire a migratory phenotype in vivo. This is enhanced by bacterial infection or activation of the Imd/JNK immune response pathway. Blocking the Imd/JNK pathway suppresses the migratory phenotype, suggesting that bacterial infection promotes the migratory behavior through activation of the immune response.
منابع مشابه
Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells.
Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human intestinal colonizer Pseudomonas aeruginosa synergizes with the Ras1V12 oncogene to induce basal invasion and dissemination of hindgut cells to distant sites. Cross-talk between...
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